Juan Gärtner的作品
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激活胰高血糖素样肽-1（GLP-1）受体的替尔泊肽（Mounjaro）肽
Organoid tissue. An organoid is a miniaturized and simplified version of an organ produced in vitro.
Major histocompatibility complex proteins (MHC) I and II on the surface of a dendritic cell
外泌体，横截面显示蛋白质和 mRNA
处于高级囊胚阶段的人类胚胎，剖面图
Enzymes involved in microRNA processing: exportin/RanGTP(light blue)) dicer/TRP, Argonaute (top right). pre-microRNA and microRNA (red)
Enzymes involved in microRNA processing: exportin/RanGTP(left)) dicer/TRP, Argonaute (right). pre-microRNA and microRNA (red)
Argonaute protein complexed with double stranded microRNA. Guide miRNA strand in red.
The dicer enzyme (blue) in complex with TRBP (violet) and precursor-microRNA (red). Dicer processes pre-microRNA to microRNA
The dicer enzyme (blue) in complex with TRBP (violet) and precursor-microRNA (red). Dicer processes pre-microRNA to microRNA
mRNA entering the cytosol through a nuclear pore
Exportin-5/RanGTP-complex transports miRNA through a nucleopore into the cytosol
Exportin-5(blue)/RanGTP(light violet)-complex transports miRNA (red) through nucleopores into the cytosol.
Nuclear pore. Nuclear pore complexes allow the transport of molecules across the nuclear envelope.
Exportin-5/RanGTP-complex transports miRNA through a nucleopore into the cytosol
let7-precursor-microRNA (50 nucleotides) and let7 microRNA (21 nucleotides), a tumor suppressor
let7-precursor-microRNA in stick and surface depiction style, a tumor suppressor
The tumor suppressor let7-precursor-microRNA
RNA hairpin structure in stick and surface style. Pre-microRNAs and tRNAs contain RNA hairpin loops.
RNA hairpin structure. Pre-microRNAs and tRNAs contain RNA hairpin loops.
The GLP-receptor agonist tirzepatide (Mounjaro) before binding and bound to the receptor
GLP-1 受体，非活性形式（左）和与激动剂（司美格鲁肽）和 G 蛋白的活性复合物
Structure of a nuclear pore. The cytosol is on top. mRNA molecules (red) and proteins are visible in the nucleus
mRNA entering the cytosol through a nuclear pore
囊性纤维化跨膜传导调节因子，CFTR关闭（左）和结合ATP（红色）的开放形式
路易体的组成成分
钠-葡萄糖协同转运蛋白 2（SGLT2）与抑制剂复合物，可降低血糖水平
Exportin-5/RanGTP/miRNA-complex
LDL particles. Low-density lipoprotein particles transport lipids like cholesterol, phospholipids and triglycerids
脂肪组织中的脂肪细胞
一种新的抗生素（zosurabalpin）在鲍氏不动杆菌的膜间转运蛋白中捕获脂多糖
G 蛋白偶联受体：视紫红质（左）和 T 细胞、多巴胺和 GABA B 受体
癌基因：DNA 突变导致 KRAS 蛋白突变
阿尔茨海默病的免疫疗法。抗体与β-淀粉样蛋白纤维结合。
Epigenetics: DNA methylation by the DNA methyl transferase I (DMNT1)
路易体神经元
HER3 (inactive conformation), a key receptor in cancer immunotherapy
26S 蛋白酶体。蛋白酶体降解不需要或受损的蛋白质
表皮生长因子受体的非活性（左）和活性（右）形式
淀粉样β蛋白（左）及其错误折叠形式（右）。淀粉样斑块，阿尔茨海默病。
Oxycodone (Oxycontin) about to bind to an opioid receptor
RNA 聚合酶 II 将 DNA 转录为 RNA
Ca2+/钙调蛋白依赖性蛋白激酶 II 全酶
A new antibiotic (zosurabalpin) traps lipopolysaccharide in the intermembrane transporter of Acinetobacter baylyi
PETase 酶将 PET 分子分解为单体构件。PETase 是一种具有塑料回收潜力的细菌酶。
G protein-coupled receptors: rhodopsin (left) and the T-cell, dopamine and GABA B receptors
人血清白蛋白分子
Chimeric antigen receptor (CAR) therapy: Engineered receptor on a T-cell binds to CD19-antigen on a leukemia cell
Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokine secretion and pyroptosis
The NLRP3 inflammasome (hexamer)
克罗恩病 - 肠道疾病
抗原结合的 IgM 激活 C1 复合物
结合细胞膜的 T 细胞受体结构
Calmodulin, a crucial messenger protein
肠道肿瘤
B 细胞受体二聚体结合抗原
关键脑受体：NMDA、AMPA 和 GABA 受体及其神经递质
GLP-1 受体，失活并被激动剂（司美格鲁肽，红色）和 G 蛋白包围
Somatostatin about to bind to the somatostatin receptor
The capsaicin receptor TRPV1 with 4 ligand analogons bound. TRPV1 is an ion channel that senses heat, regulates the body temperature and contributes to pain sensation. Source: PDB entry 5is0.
核糖体将 mRNA 翻译成多肽链
嵌合抗原受体（CAR）疗法：工程 T 细胞攻击白血病细胞
雷帕霉素抑制 mTORC1
免疫检查点抑制剂：治疗性抗体阻断 PD-1 和 PD-L1 之间的相互作用
分裂的癌细胞
人体肠道中的细菌
Carbon dioxide (CO2) fixing enzyme: enoyl-CoA carboxylase/reductase
Glucose about to bind to the sweet taste receptor
RNA hairpin structure
T-cell receptors and CD8 and CD4 co-receptors on a killer and a helper T-cell
T-cell receptors and CD8 and CD4 co-receptors on a killer and a helper T-cell
Major histocompatibility complex proteins (MHC) I and II on the surface of a dendritic cell. Left MHC I, right MCH II. MHCII presents generally longer antigenic peptides (red) than MHC I.
Dimeric low density lipoprotein (LDL) receptor (light blue) binding LDL particles
表观遗传学：DNA 甲基转移酶 I（DMNT1）使 DNA 甲基化
表观遗传学：DOT1L 甲基化泛素化核小体的组蛋白
癌症抗原间皮素
胰岛素受体失活（左）和激活（右）之后
抗原结合的 IgM 激活 C1 复合物。补体激活的经典途径。
RNA 聚合酶 II 将 DNA 转录为 RNA。
Activation of rhodopsin by light leads to the hyperpolarization of photoreceptor cells
带有路易小体的神经元
Transcription and translation: from DNA to a protein
GLP-1 receptor, activated complex with an agonist (semaglutide) and G-proteins
胰岛素分子。胰岛素是一种调节碳水化合物和脂肪代谢的蛋白质激素
Chromatin strand and isolated nucleosome
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